As reported in China Daily, an increase of mycoplasma pneumoniae infections in China was observed in May 2023 by Zhou Huixia, director of a children's medical centre, with a "rapid increase" in August and a "particularly ferocious" wave starting in early October. On 24 October 2023, Zhou predicted that the wave would peak in November.[5]
On 13 November, authorities from China's National Health Commission reported an increase in respiratory diseases. The increase in these diseases was attributed to the lifting of COVID-19 restrictions earlier in the year, and the circulation of known pathogens including influenza, mycoplasma pneumoniae (a common bacterial infection typically affecting young children), respiratory syncytial virus (RSV), and SARS-CoV-2.[6]
On 21 November, ProMED reported clusters of undiagnosed pneumonia in children in northern China. It is unclear if these are associated with the overall increase in respiratory infections previously reported by Chinese authorities or separate events. Further information about recent trends in these known pathogens was requested by the WHO.[6] The WHO stated that during October and November, northern China had reported an "increase in influenza-like illness" compared to the corresponding period during the previous three years.[7]
On 23 November, Chinese health authorities claimed that the increase in respiratory diseases was not attributed to any novel or unknown pathogens but was relevant to known pathogens. Later, WHO verifies that no novel or unknown pathogens have been discovered so far, and the clinical features of the diseases are not unusual.[8]
On 27 November, a journal article published in Nature indicated that there are many multiple anomalies behind the dramatic increase in respiratory disease cases in China. First, usually, the infection caused by Mycoplasma pneumoniae is easy to treat, but, in this case in China, the infection causes serious impact on Chinese children. Second, after the lifting of COVID-19 restrictions, cases reported by some of the countries are virus infections; in contrast, the major cases reported by China, particularly, are mycoplasma pneumoniae, a disease whose infection is caused by bacteria.[9]