21-hydroxysteroid dehydrogenase (NADP+)
Enzyme
From Wikipedia, the free encyclopedia
In enzymology, 21-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.151) is an enzyme that catalyzes the chemical reaction
-pregnan-21-al.svg)
-pregnan-21-ol.svg)
| 21-hydroxysteroid dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.151 | ||||||||
| CAS no. | 37250-76-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme are (5β)-pregnan-21-ol and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are (5β)-pregnan-21-al, reduced NADPH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NADP+ 21-oxidoreductase. Other names in common use include 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), dehydrogenase, 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide, phosphate), NADP+-21-hydroxysteroid dehydrogenase, and 21-hydroxysteroid dehydrogenase (NADP+).
See also
- 21-hydroxysteroid dehydrogenase (NAD+), an enzyme which catalyses the same reaction but using an alternative cofactor
