24-hydroxycholesterol 7alpha-hydroxylase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, a 24-hydroxycholesterol 7alpha-hydroxylase (EC 1.14.14.26) is an enzyme that catalyzes the chemical reaction
-7α,24-dihydroxycholesterol.svg)
| 24-hydroxycholesterol 7alpha-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.26 | ||||||||
| CAS no. | 288309-90-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The four substrates of this enzyme are 24S-hydroxycholesterol, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are (24S)-7α,24-dihydroxycholesterol, oxidised NADP+, and water.[1][2][3]
This enzyme is a cytochrome P450-type oxidoreductase, acting on paired donors, with molecular oxygen as oxidant and incorporating one of its atoms. The systematic name of this enzyme class is (24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating). Other names in common use include 24-hydroxycholesterol 7alpha-monooxygenase, CYP39A1, and CYP39A1 oxysterol 7alpha-hydroxylase.[4]
