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25T7-NBOMe

Chemical compound From Wikipedia, the free encyclopedia

25T7-NBOMe, also known as 2C-T-7-NBOMe or NBOMe-2C-T-7 as well as N-(2-methoxybenzyl)-4-propylthio-2,5-dimethoxyphenethylamine, is a serotonergic psychedelic of the 25-NB (NBOMe) family. It is the NBOMe analogue of 2C-T-7. The compound has been sold as a designer drug.[2][3][4][5][6]

Other names2C-T-7-NBOMe; NBOMe-2C-T-7; N-(2-Methoxybenzyl)-4-propylthio-2,5-dimethoxyphenethylamine
Drug classSerotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Legal status
Quick facts Clinical data, Other names ...
25T7-NBOMe
Clinical data
Other names2C-T-7-NBOMe; NBOMe-2C-T-7; N-(2-Methoxybenzyl)-4-propylthio-2,5-dimethoxyphenethylamine
Drug classSerotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Legal status
Legal status
Identifiers
  • 2-(2,5-dimethoxy-4-propylsulfanylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H29NO3S
Molar mass375.53 g·mol−1
3D model (JSmol)
  • CCCSC1=C(C=C(C(=C1)OC)CCNCC2=CC=CC=C2OC)OC
  • InChI=1S/C21H29NO3S/c1-5-12-26-21-14-19(24-3)16(13-20(21)25-4)10-11-22-15-17-8-6-7-9-18(17)23-2/h6-9,13-14,22H,5,10-12,15H2,1-4H3
  • Key:CPVMNHOHOSNFOP-UHFFFAOYSA-N
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Use and effects

The active dose range and route of 25T7-NBOMe do not appear to have been described.[7]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

More information Target, Affinity (Ki, nM) ...
25T7-NBOMe activities
TargetAffinity (Ki, nM)
5-HT1A1,800–>10,000
5-HT1B1,902–>10,000
5-HT1D1,349–2,176
5-HT1E>10,000
5-HT1FND
5-HT2A0.68–1.16 (Ki)
7.42–260 (EC50Tooltip half-maximal effective concentration)
41–173% (EmaxTooltip maximal efficacy)
5-HT2B2.16–2.3 (Ki)
310 (EC50)
14% (Emax)
5-HT2C1.33–6.4 (Ki)
19.1 (EC50)
95% (Emax)
5-HT3>10,000
5-HT4ND
5-HT5A>10,000
5-HT662.4–68.8
5-HT7>10,000
α1A340–490
α1B>10,000
α1D1,429
α2A226–360
α2B603
α2C479
β1ND
β24,266
β32,163
D14,100
D21,000
D3153–1,400
D4186
D5ND
H1403–1,200
H21,000
H3–H4ND
M1–M5ND
I1ND
σ119.1
σ222.6
MOR944
DOR>10,000
KOR148
TAAR1Tooltip Trace amine-associated receptor 11,000 (Ki) (mouse)
88–90 (Ki) (rat)
2,100 (EC50) (mouse)
550 (EC50) (rat)
>10,000 (EC50) (human)
68% (Emax) (mouse)
52% (Emax) (rat)
SERTTooltip Serotonin transporter1,514–3,200 (Ki)
17,000 (IC50Tooltip half-maximal inhibitory concentration)
ND (EC50)
NETTooltip Norepinephrine transporter3,700–>10,000 (Ki)
34,000 (IC50)
ND (EC50)
DATTooltip Dopamine transporter2,344 (Ki)
55,000 (IC50)
ND (EC50)
Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs: [8][9][10][2][3][11][12]
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25T7-NBOMe acts as a highly potent and selective agonist of the serotonin 5-HT2 receptors.[2] Its affinities and activities at a variety of other receptors and transporters have also been described.[2]

History

25T7-NBOMe was first described in the scientific literature by 2012.[13]

Society and culture

Canada

25T7-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.[14]

See also

References

External links

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