2C-P

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists 2C-P's dose range as 6 to 10 mg orally and its duration as 10 to 16 hours.^[1] A wider dosage range of 1 to 16 mg or more, with a typical dose estimate of 7 mg, has also been reported.^[4] Shulgin wrote in PiHKAL that while most reports with doses of 6 to 12 mg were positive, a single report of 16 mg was described as a clear overdose and "physical disaster" that was "not to be repeated".^[1] He described the drug as having a steep dose–response curve and advised careful individual dose titration.^[1] 2C-P is also said to come on slowly, with an onset of 1 to 2 hours and peak effects not occurring until after 3 hours.^[1] The drug is one of the most potent psychedelics of the 2C family, rivaled only by 2C-TFM.^[1][2] It is taken orally.^[1]

The effects of 2C-P have been reported to include closed-eye imagery, beautiful psychedelic visuals, insights, emotional enhancement, increased appreciation of music and eroticism, feelings of energy flowing through oneself, physical discomfort, back and leg pain, next-day hangover, and an afterglow.^[1]

Unknown or unreported doses taken by teenagers at a Connecticut, United States concert in September 2013 caused seven people to require emergency medical help including CPR and defibrillation to resuscitate some of them, with all seven being taken to a hospital and four of those being hospitalized until at least the next day.^[5] It was reported that none of the overdose victims died^[6] while CNN's "OutFront" blog claimed the police called it a "mass casualty event"^[7] blaming the problems on 2C-P and drugs apparently being sold as "Molly", a common name for MDMA.

Louella Fletcher-Michie, the daughter of actor John Michie, died from a 2C-P overdose in September 2017 at the Bestival festival in Dorset, United Kingdom, the first reported death from 2C-P.^[8] Her boyfriend was found guilty of manslaughter, for giving her the drug and failing to act to help her for over six hours after she overdosed. His conviction for failing to act was quashed in August 2020.^[9]

2C drugs like 2C-P are known to be metabolized by the monoamine oxidase (MAO) enzymes MAO-A and MAO-B.^[10][11] Monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, moclobemide, and selegiline may potentiate the effects of 2C drugs like 2C-P.^[10][11][12] This may result in overdose and serious toxicity.^[12][10]

2C-P is 2,5-dimethoxy-4-n-propylphenethylamine. The full name of the chemical is 2-(2,5-dimethoxy-4-propylphenyl)ethanamine. The hydrochloride salt is the most common form, normally found as a white powder,^{[20][unreliable source?]} or white crystals.^[1]

2C-P was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved) in 1991.^[1]

• 2C (psychedelics)