2CD-5EtO

2CD-5EtO, also known as 5-ethoxy-2-methoxy-4-methylphenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to 2C-D.^[1][2][3] It is the analogue of 2C-D in which the methoxy group at the 5 position has been extended to an ethoxy group.^[1][2][3]

Other names2C-D-5-EtO; 2CD-5-EtO; 5-Ethoxy-2-methoxy-4-methylphenethylamine; 2-Methoxy-5-ethoxy-4-methylphenethylamine; 4-Methyl-2-methoxy-5-ethoxyphenethylamine; 2-Methoxy-4-methyl-5-ethoxyphenethylamine

Routes of
administrationOral^[1]

Drug classPsychoactive drug

Onset of action~2 hours (peak)^[1]

Quick facts Clinical data, Other names ...

2CD-5EtO

Clinical data
Other names	2C-D-5-EtO; 2CD-5-EtO; 5-Ethoxy-2-methoxy-4-methylphenethylamine; 2-Methoxy-5-ethoxy-4-methylphenethylamine; 4-Methyl-2-methoxy-5-ethoxyphenethylamine; 2-Methoxy-4-methyl-5-ethoxyphenethylamine
Routes of administration	Oral[1]
Drug class	Psychoactive drug
Pharmacokinetic data
Onset of action	~2 hours (peak)[1]
Duration of action	12 hours[1][2][3]
Identifiers
IUPAC name 1-(5-ethoxy-2-methoxy-4-methylphenyl)-ethan-1-amine
CAS Number	1354634-32-4 N
PubChem CID	57458864
ChemSpider	26234937 Y
UNII	8HT47SKY9C
CompTox Dashboard (EPA)	DTXSID701029521
Chemical and physical data
Formula	C12H19NO2
Molar mass	209.289 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC1=CC(=C(C=C1C)OC)CCN
InChI InChI=1S/C12H19NO2/c1-4-15-11-8-10(5-6-13)12(14-3)7-9(11)2/h7-8H,4-6,13H2,1-3H3 Y Key:ZMQDQUPRBYFPSO-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2CD-5EtO's dose as 40 to 50 mg orally, its onset as slow and gradual, its time to peak or full effects as about 2 hours, and its duration as 12 hours.^[1][2][3] The effects of 2CD-5EtO were said to include being "largely free from excitement", having "a friendly openness and outgoingness that allowed easy talk, interaction, humor", and allowing for healthy appetite.^[1]

The chemical synthesis of 2CD-5EtO has been described.^[1]

2CD-5EtO was first described in the literature by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) in 1991.^[1] It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.^{[2][4][5][6][7]} 2CD-5EtO is a controlled substance in Canada under phenethylamine blanket-ban language.^[8]