TWEETIO

TWEETIO is a family of phenethylamine psychedelic drugs.^[1][2][3][4] They are analogues of the 2C drugs (4-substituted 2,5-dimethoxyphenethylamines) in which one or both of the methoxy groups at positions 2 and 5 of the phenyl ring have been lengthened to ethoxy groups.^[1][2][4] Examples include 2CD-2-ETO (a TWEETIO of 2C-D), 2CE-5-ETO (a TWEETIO of 2C-E), and 2CT2-5-ETO (a TWEETIO of 2C-T-2), among many others.^[1][2][3][4]

The TWEETIO drugs are said to have been named in a humorous way by pronouncing the simplest structural form of "2-EtO-X".^[1][5] Limited human data are available on the TWEETIO compounds.^[1][2][5][4] In any case, some generalizations have been made, including that the 2-ETO compounds tend to have a shorter duration and decreased potency, the 5-ETO drugs tend to have enhanced potency and remarkably increased durations, and the 2,5-Di-ETO drugs tend to be inactive.^[1][2][5]

The TWEETIO compounds were developed by Darrell Lemaire as potential "smart drugs" in the 1970s or 1980s.^[6][7][8][9] The compounds were described in the scientific literature by Alexander Shulgin via personal communication with Lemaire in the 1990s and 2000s.^[5][1][2][4] It was said by Shulgin in 2003 that the propoxy analogues had not yet been synthesized.^[1] In 2023, the propoxy derivative ASR-2001 (2CB-5PrO) was reported by Nick Cozzi and Paul F. Daley of the Alexander Shulgin Research Institute.^{[10][11][12][13][14]} It is under development for potential medical use.^{[10][11][12][13]}