3-Iodotyrosine
Chemical compound
From Wikipedia, the free encyclopedia
3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones which is derived from iodination of tyrosine at the meta-position of the benzene ring. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle. Two units can combine to form 3,3'-diiodothyronine.
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 3-Iodo-L-tyrosine | |
| Names | |
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| IUPAC name
3-Iodotyrosine | |
| Systematic IUPAC name
2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | |
| Other names
Monoiodotyrosine; MIT[1] | |
| Identifiers | |
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3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.000.677 |
| MeSH | Monoiodotyrosine |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C9H10INO3 | |
| Molar mass | 307.087 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase.[2]
Relevance in dopamine studies
3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels.[3]