3C-E
Psychedelic drug
From Wikipedia, the free encyclopedia
3C-E, also known as 4-ethoxy-3,5-dimethoxyamphetamine or as α-methylescaline (3C-escaline), is a psychedelic drug of the phenethylamine, amphetamine, and 3C families related to 3,4,5-trimethoxyamphetamine (TMA).[1][5][3] It is the amphetamine (3C) analogue of escaline.[1][3]
- CA: Schedule I
- DE: NpSG (Industrial and scientific use only)
- UK: Class B
- US: Analogue of a Schedule I drug, possibly illegal under the Federal Analog Act
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| Other names | 4-Ethoxy-3,5-dimethoxyamphetamine; 3,5-Dimethoxy-4-ethoxyamphetamine; α-Methylescaline; 3C-Escaline |
| Routes of administration | Oral[1][2][3][4] |
| Drug class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Duration of action | 8â12 hours[1][3] |
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| Formula | C13H21NO3 |
| Molar mass | 239.315 g·molâ1 |
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Use and effects
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 3C-E's dose as 30 to 60 mg orally and its duration as 8 to 12 hours.[1][2][5][3] Per other sources, it has an estimated typical dose of 45 mg orally.[4] The drug has about the same potency as escaline.[1][2][6]
The effects of 3C-E have been described as including strong visuals, closed-eye imagery like bright colors and distinct shapes, complex fantasy, strangeness, unworldliness, and unreality, an eerie state of awareness, fluctuating erotic and anti-erotic feelings, "exquisite sensitivity", heavy body discomfort, feelings of toxicity, nausea, muscle tremors, malaise, and slight teeth clenching.[1] Shulgin concluded that it was a fascinating compound, but that it was a little too heavy on the body for most subjects.[1]
Interactions
Pharmacology
Pharmacodynamics
3C-E is a potent serotonin 5-HT2A receptor agonist and also interacts with other serotonin receptors and targets.[3][5] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[7][4]
Chemistry
History
3C-E was first described in the scientific literature by Benington and colleagues in 1954.[8] Alexander Shulgin and colleagues reported an active dose of 40 mg orally based on unpublished findings in a 1978 literature review.[9][10] Subsequently, Shulgin further reported the properties and effects of 3C-E in his book PiHKAL (Phenethylamines I Have Known and Loved) in 1991.[1] The drug was encountered as a novel designer drug in Europe in 2013.[11][12][7]
Society and culture
Legal status
Canada
It is a controlled substance in Canada under phenethylamine blanket-ban language.[13]