4-AcO-EPT

4-AcO-EPT, also known as 4-acetoxy-N-ethyl-N-propyltryptamine, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin).^[1][2] It is the acetate ester of 4-HO-EPT (eprocin) and is thought to act as a prodrug of 4-HO-EPT.^[3][1][2] Based on online anecdotal reports, 4-AcO-EPT is said to have a dose of 20 to 30 mg orally.^[1] It shows reduced affinity and agonistic potency at serotonin receptors, including the serotonin 5-HT_2A receptor, compared to 4-HO-EPT.^[3][4] Similarly to 4-HO-EPT, 4-AcO-EPT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and does so with comparable potency, in line with it being a prodrug.^[3] 4-AcO-EPT was encountered as a novel designer drug online in 2018, in Europe in 2020, and in the United States in 2021.^[1][2]

Other names4-Acetoxy-EPT; 4-Acetoxy-N-ethyl-N-propyltryptamine; 4-HO-EPT AC; 4-OH-EPT AC

Routes of
administrationOral^[1]

Drug classSerotonin receptor agonist; Serotonin 5-HT_2A receptor agonist; Serotonergic psychedelic; Hallucinogen

ATC code

• None

Quick facts Clinical data, Other names ...

4-AcO-EPT

Clinical data
Other names	4-Acetoxy-EPT; 4-Acetoxy-N-ethyl-N-propyltryptamine; 4-HO-EPT AC; 4-OH-EPT AC
Routes of administration	Oral[1]
Drug class	Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code	None
Identifiers
IUPAC name [3-[2-[ethyl(propyl)amino]ethyl]-1H-indol-4-yl] acetate
CAS Number	2750249-90-0
PubChem CID	138454311
ChemSpider	112747177
CompTox Dashboard (EPA)	DTXSID001343207
Chemical and physical data
Formula	C17H24N2O2
Molar mass	288.391 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCN(CC)CCC1=CNC2=C1C(=CC=C2)OC(=O)C
InChI InChI=1S/C17H24N2O2/c1-4-10-19(5-2)11-9-14-12-18-15-7-6-8-16(17(14)15)21-13(3)20/h6-8,12,18H,4-5,9-11H2,1-3H3 Key:VMFRFQVZMZGHOK-UHFFFAOYSA-N

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