4-NEMD

4-NEMD is a potent sedative drug which acts as a selective alpha-2 adrenergic receptor agonist. It is closely related to dexmedetomidine but is several times more potent.^[1] Like other alpha-2 agonists, it produces sedative and muscle relaxant effects but without producing respiratory depression. It is not currently used in medicine, but has been researched as the basis for a potential new generation of alpha-2 agonist drugs,^[2][3] which may have selectivity for the different subtypes of the alpha-2 receptor.^[4] It has two isomers, with the (S) isomer being the more potent, as with medetomidine.^[5] 4-NEMD was also investigated by the United States military as an anesthetic agent, most likely for use in surgery, but possibly also for use as a non-lethal incapacitating agent, although this has not been officially confirmed.^[6]

ATC code

• None

CAS Number

• 156833-39-5 ^Y

PubChem CID

• 132110

ChemSpider

• 24531958 ^Y

Quick facts Clinical data, ATC code ...

4-NEMD

Clinical data
ATC code	None
Identifiers
IUPAC name (S)-4-(1-Naphthalen-1-ylethyl)-1H-imidazole
CAS Number	156833-39-5 Y
PubChem CID	132110
ChemSpider	24531958 Y
UNII	H3R6PW4CUC
CompTox Dashboard (EPA)	DTXSID501237378
Chemical and physical data
Formula	C15H14N2
Molar mass	222.291 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C1=CC=CC2=CC=CC=C21)C3=CN=CN3
InChI InChI=1S/C15H14N2/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13/h2-11H,1H3,(H,16,17)/t11-/m0/s1 Y Key:DZSQSLQSMKNVBV-NSHDSACASA-N Y
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