4-PrO-MET

4-PrO-MET, also known as 4-propionyloxy-N-methyl-N-ethyltryptamine or as O-propionyl-4-HO-MET, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin).^[1][2] It is thought to be a prodrug of 4-HO-MET (metocin) similarly to 4-AcO-MET (metacetin).^[1][2] 4-PrO-MET was encountered online as a novel designer drug in August or September 2025.^[1][2] It is anecdotally claimed to produce more intense psychedelic visuals than psilocin (4-HO-DMT) but to be "less heavy" and to have good tolerability.^[1] 4-PrO-MET is not an explicitly controlled substance in the United States^[3] or in Canada.^[4]

Other names4-Propionyloxy-MET; 4-Propionyloxy-N-methyl-N-ethyltryptamine; O-Propionyl-4-HO-MET; O-Propionylmetocin

Routes of
administrationOral^[1]

Drug classSerotonergic psychedelic; Hallucinogen

ATC code

• None

Quick facts Clinical data, Other names ...

4-PrO-MET

Clinical data
Other names	4-Propionyloxy-MET; 4-Propionyloxy-N-methyl-N-ethyltryptamine; O-Propionyl-4-HO-MET; O-Propionylmetocin
Routes of administration	Oral[1]
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None
Identifiers
IUPAC name [3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-yl] propanoate
PubChem CID	169222171
Chemical and physical data
Formula	C16H22N2O2
Molar mass	274.364 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(=O)OC1=CC=CC2=C1C(=CN2)CCN(C)CC
InChI InChI=1S/C16H22N2O2/c1-4-15(19)20-14-8-6-7-13-16(14)12(11-17-13)9-10-18(3)5-2/h6-8,11,17H,4-5,9-10H2,1-3H3 Key:ACMPLXDHJQJMIW-UHFFFAOYSA-N

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