4-Thiosymbescaline
Pharmaceutical compound
From Wikipedia, the free encyclopedia
4-Thiosymbescaline (4-TSB), also known as 3,5-diethoxy-4-methylthiophenethylamine, is a chemical compound of the phenethylamine and scaline families related to mescaline.[1][2][3][4] It is the analogue of symbescaline in which the methoxy group at the 4 position has been replaced with a methylthio group.[1][2][3][4] The compound is one of two possible thiosymbescaline (TSB) positional isomers, the other being 3-thiosymbescaline (3-TSB).[1][2][3][4]
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| Other names | 4-TSB; 3,5-Diethoxy-4-methylthiophenethylamine; 3-EtO-4-MeS-5-EtO-PEA |
| Routes of administration | Oral[1] |
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| Duration of action | Unknown[1] |
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| Formula | C13H21NO2S |
| Molar mass | 255.38 g·mol−1 |
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In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 4-TSB's dose as greater than 240 mg orally and its duration as unknown.[1][2][3] The effects of 4-TSB have been reported to include a "real effect" and a little spaciness at 80 mg orally, twinges at 160 mg orally, and "no effects at all" at 240 mg orally.[1] It was concluded that the compound is probably inactive.[1]
The chemical synthesis of 4-TSB has been described.[1][4]
4-TSB was first described in the scientific literature by Shulgin and Peyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1]