4-Thiomescaline
Pharmaceutical compound
From Wikipedia, the free encyclopedia
4-Thiomescaline (4-TM), or simply thiomescaline, also known as 3,5-dimethoxy-4-methylthiophenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline (3,4,5-trimethoxyphenethylamine).[1][3][4][2][5] It is the analogue of mescaline in which the methoxy group at the 4 position has been replaced with a methylthio group.[1][3][4][5] The drug is one of two possible thiomescaline (TM) positional isomers, the other being 3-thiomescaline (3-TM).[1][3][4][5]
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| Other names | 4-TM; Thiomescaline; 3,5-Dimethoxy-4-methylthiophenethylamine; 4-Methylthio-3,5-dimethoxyphenethylamine; 3-MeO-4-MeS-5-MeO-PEA |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic; Hallucinogen |
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| Onset of action | 30–60 minutes[1][2] |
| Duration of action | 10–15 hours[1] |
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| Formula | C11H17NO2S |
| Molar mass | 227.32 g·mol−1 |
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In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 4-TM's dose as 20 to 40 mg orally and its duration as 10 to 15 hours.[1][3][4][2][5] Its onset is 30 to 60 minutes.[1][2] The drug has about 10 times the potency of mescaline.[1][3][4][5][6][7][8] The effects of 4-TM have been reported to include slight color enhancement, closed-eye imagery, fantasy, feeling strange, feelings of unreality, visions of Möbius strips, introspection, insights, lightheadedness, physical uneasiness, tremor, abdominal cramps, walking difficulty, appetite loss, and parasthesia.[1][2][5] Shulgin described it as a "mixed bag of responses".[1] It was described as being more similar in its effects to LSD than to mescaline and as being similar in effects to the Aleph series.[1][2]
The chemical synthesis of 4-TM has been described.[1][5][2]
4-TM was first synthesized and tested in 1977 and was described in the literature by Shulgin and colleagues in 1978.[4][2][5] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1]