4F-4PP

4F-4PP, or 4F4PP, also known as 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)piperidine, is a selective serotonin 5-HT_2A receptor antagonist which is used in scientific research.^[1]^[2]^[3]

Other names4F4PP; FPPO; 4-PBFBP; FBP; 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine; N-(4-Phenylbutyl)-4-(4-fluorobenzoyl)piperidine

Drug classSerotonin 5-HT_2A receptor antagonist

ATC code

None

CAS Number

120357-05-3
144734-36-1 (oxalate)

Quick facts Clinical data, Other names ...

4F-4PP
Clinical data

Other names	4F4PP; FPPO; 4-PBFBP; FBP; 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine; N-(4-Phenylbutyl)-4-(4-fluorobenzoyl)piperidine
Drug class	Serotonin 5-HT_2A receptor antagonist
ATC code	None
Identifiers
IUPAC name (4-fluorophenyl)-[1-(4-phenylbutyl)piperidin-4-yl]methanone
CAS Number	120357-05-3 144734-36-1 (oxalate)
PubChem CID	5234410
ChemSpider	4403727
ChEBI	CHEBI:104176
ChEMBL	ChEMBL19259
Chemical and physical data
Formula	C₂₂H₂₆FNO
Molar mass	339.454 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCCCC3=CC=CC=C3
InChI InChI=1S/C22H26FNO/c23-21-11-9-19(10-12-21)22(25)20-13-16-24(17-14-20)15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-12,20H,4-5,8,13-17H2 Key:FTJXZACAQRDRNT-UHFFFAOYSA-N

Pharmacology

4F-4PP shows high affinity for the serotonin 5-HT_2A receptor (K_i = 5.3 nM) and 120-fold lower affinity for the serotonin 5-HT_2C receptor (K_i = 620 nM).^[1]^[3] For comparison, ketanserin showed only 14-fold higher affinity for the serotonin 5-HT_2A receptor over the serotonin 5-HT_2C receptor in the same study.^[1] In a functional assay, 4F-4PP was 204-fold more potent as a serotonin 5-HT_2A receptor antagonist than as a serotonin 5-HT_2C receptor antagonist.^[2] The drug does not appear to block the serotonin 5-HT_2B receptor.^[4] It showed limited and non-significant effects on the oxytocin and vasopressin secretion induced by the serotonin 5-HT_2A and 5-HT_2C receptor agonist and serotonergic psychedelic DOI in rodents.^[3]

Chemistry

Analogues

A radiolabeled isotopologue for use in positron emission tomography (PET) imaging has been described.^[5]

History

4F-4PP first described in the scientific literature by 1992.^[1] It is an analogue of and was derived via structural modification of ketanserin.^[1]

References

[1]
Herndon JL, Ismaiel A, Ingher SP, Teitler M, Glennon RA (December 1992). "Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding". Journal of Medicinal Chemistry. 35 (26): 4903–4910. doi:10.1021/jm00104a017. PMID 1479590.
[2]
Acuña-Castillo C, Villalobos C, Moya PR, Sáez P, Cassels BK, Huidobro-Toro JP (June 2002). "Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT(2A) and 5-HT(2C) receptors". British Journal of Pharmacology. 136 (4): 510–519. doi:10.1038/sj.bjp.0704747. PMC 1573376. PMID 12055129.
[3]
Jørgensen H, Riis M, Knigge U, Kjaer A, Warberg J (March 2003). "Serotonin receptors involved in vasopressin and oxytocin secretion". Journal of Neuroendocrinology. 15 (3): 242–249. doi:10.1046/j.1365-2826.2003.00978.x. PMID 12588512. Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. We investigated the involvement of 5-HT receptors in the serotonergic regulation of vasopressin and oxytocin secretion. Vasopressin and oxytocin secretion was stimulated by [...] the 5-HT2A+2C agonist DOI, [...] The 5-HT2A antagonist 4-(4-flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate had no effect on DOI-induced hormone response. [...] We conclude that 5-HT-induced vasopressin secretion primarily is mediated via 5-HT2C, 5-HT4 and 5-HT7 receptors, whereas 5-HT2A, 5-HT3 and 5-HT5A receptors seem to be of minor importance. 5-HT-induced oxytocin secretion involves 5-HT1A, 5-HT2C and 5-HT4 receptors; in addition an involvement of 5-HT1B, 5-HT5A and 5-HT7 receptors seems likely, whereas 5-HT2A and 5-HT3 receptors seem to be less important. [...] The following 5-HT receptor antagonists were used: [...] the 5-HT2A antagonist 4-(4- flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate (FBP); [...] FIG. 4. Vasopressin (A; AVP) or oxytocin (B; OT) response to: (I) the 5-HT2Aþ2C agonist DOI (20 nmol) after pretreatment with the 5-HT2A antagonist 4-(4- flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate (FBP; 1, 10 or 100 nmol), [...] TABLE 2. Receptor Affinities for the 5-HT Antagonists Expressed as pKi Values. [...] FBP = 4-(4-flourobenzoyl)- 1-(4-phenylbutyl)-piperidine oxalate.
[4]
Sandén N, Thorlin T, Blomstrand F, Persson PA, Hansson E (April 2000). "5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions". Neurochemistry International. 36 (4–5): 427–434. doi:10.1016/s0197-0186(99)00134-5. PMID 10733010.
[5]
Hashimoto K, Hatano K, Minabe Y, Iyo M, Taniguchi M, Hoshino O, et al. (1998). "Radiosynthesis of [18F]N-(4-phenylbutyl)-4-(4-fluorobenzoyl)piperidine for studying serotonin 5-HT2a receptors". Journal of Labelled Compounds and Radiopharmaceuticals. 41 (10): 941–949. doi:10.1002/(SICI)1099-1344(1998100)41:10<941::AID-JLCR151>3.0.CO;2-6.

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