5-(Nonyloxy)tryptamine

5-(Nonyloxy)tryptamine
Clinical data
Other names	5-NOT; 5-(Nonyloxy)-1H-indole-3-ethanamine
Identifiers
	IUPAC name 2-(5-Nonyloxy-1H-indol-3-yl)ethanamine;
CAS Number	157798-12-4 ;
PubChem CID	1797;
IUPHAR/BPS	106;
ChemSpider	1731 ;
UNII	TV6CHD9VPT;
ChEBI	CHEBI:64149;
ChEMBL	ChEMBL97450;
CompTox Dashboard (EPA)	DTXSID4058653 ;
Chemical and physical data
Formula	C19H30N2O
Molar mass	302.462 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCCCCOC1=CC2=C(C=C1)NC=C2CCN;
	InChI InChI=1S/C19H30N2O/c1-2-3-4-5-6-7-8-13-22-17-9-10-19-18(14-17)16(11-12-20)15-21-19/h9-10,14-15,21H,2-8,11-13,20H2,1H3 ; Key:YHSMSRREJYOGQJ-UHFFFAOYSA-N ;
	(what is this?) (verify)

5-(Nonyloxy)tryptamine (5-NOT) is a tryptamine derivative which acts as a selective agonist at the 5-HT_1B receptor. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT_1B, with highest activity found for the nonyloxy derivative, having a 5-HT_1B binding affinity of 1.0 nM, and around 300-fold selectivity over the related 5-HT_1A receptor.^[1]^[2]