5-Iodowillardiine

5-Iodowillardiine is a selective agonist for some kainate receptor subunits with only limited effects at AMPA receptors.^[1] It activates kainate receptors containing GluK1 (GluR5) or GluK5 (KA2) subunits, but it does not act on GluK2 (GluR6) subunits.^[2][3][4][5] It is an excitotoxic neurotoxin in vivo,^[6][7] but has proved highly useful for characterising the subtypes and function of the various kainate receptors in the brain and spinal cord.^[8][9][10]

Quick facts Names, Identifiers ...

5-Iodowillardiine

Names
IUPAC name (2S)-2-Amino-3-(5-iodo-2,4-dioxopyrimidin-1-yl)propanoic acid
Identifiers
CAS Number	140187-25-3 N
3D model (JSmol)	Interactive image Interactive image
ChEMBL	ChEMBL121915 Y
ChemSpider	394358 Y
DrugBank	DB02818 Y
IUPHAR/BPS	4071
PubChem CID	447196
UNII	JA824MLW6G Y
CompTox Dashboard (EPA)	DTXSID90332246
InChI InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 Y Key: AXXYLTBQIQBTES-BYPYZUCNSA-N Y InChI=1/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 Key: AXXYLTBQIQBTES-BYPYZUCNBL
SMILES C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)I O=C(O)[C@@H](N)CN1/C=C(/I)C(=O)NC1=O
Properties
Chemical formula	C7H8IN3O4
Molar mass	325.061 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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