5-Fluoro-AET
Chemical compound
From Wikipedia, the free encyclopedia
5-Fluoro-AET, also known as 5-fluoro-α-ethyltryptamine or by the code name PAL-545, is a substituted tryptamine derivative which acts as a serotonin–dopamine releasing agent (SDRA) and as an agonist of the serotonin 5-HT2A receptor.[1]
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| Other names | 5-Fluoro-α-ethyltryptamine; 5-F-AET; 5F-AET; 5-Fluoro-αET; 5-F-αET; 5F-αET; PAL-545 |
| Drug class | Serotonin–norepinephrine–dopamine releasing agent; Serotonin receptor agonist; Entactogen |
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| Formula | C12H15FN2 |
| Molar mass | 206.264 g·mol−1 |
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Pharmacology
Pharmacodynamics
Its EC50 values for monoamine release are 36.6 nM for serotonin, 5,334 nM for norepinephrine, and 150 nM for dopamine in rat brain synaptosomes.[1] Its EC50 at the serotonin 5-HT2A receptor is 246 nM and its Emax at the receptor is 87%.[1]
Several close analogues of 5-fluoro-αET, including 5-fluoro-αMT and 5-chloro-αMT, are known to be potent monoamine oxidase inhibitors (MAOIs), specifically of monoamine oxidase A (MAO-A).[2] However, α-ethyltryptamine (αET) is a very weak MAOI.[3][4] 5-Fluoro-αET has also more recently been assessed, and in contrast to αET, but similarly to drugs like 5-fluoro-αET, was found to be a potent MAOI, with an IC50 of 2,480 nM.[5] Potent monoamine oxidase inhibition by monoamine releasing agents (MRAs) has been associated with dangerous and sometimes fatal toxicity in humans.[2]
Chemistry
Analogues
Analogues of 5-fluoro-AET include α-ethyltryptamine (AET), 5-fluorotryptamine, 4-methyl-AET, 5-chloro-AET, 5-chloro-AMT, 5-fluoro-AMT, 5-fluoro-DMT, bretisilocin (5-fluoro-MET), 5-MeO-AET, 6-fluoro-AMT, 7-chloro-AMT, 7-methyl-DMT, and 7-methyl-AET, among others.
Society and culture
Legal status
Canada
5-Fluoro-AET is not an explicitly nor implicitly controlled substance in Canada as of 2025.[6]
United States
5-Fluoro-AET is not an explicitly controlled substance in the United States.[7] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.