5-MeO-AET
Chemical compound
From Wikipedia, the free encyclopedia
5-MeO-αET, also known as 5-methoxy-α-ethyltryptamine, is a psychoactive drug of the tryptamine and α-alkyltryptamine families.[1] It reportedly produces psychedelic and stimulant effects.[1][2]
 | |
 | |
| Clinical data | |
|---|---|
| Other names | 5-Methoxy-α-ethyltryptamine; 5-MeO-αET; 5-MeO-AET |
| Routes of administration | Oral[1] |
| Drug class | Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen |
| Legal status | |
| Legal status | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C13H18N2O |
| Molar mass | 218.300 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 201 to 203 °C (394 to 397 °F) |
| |
| |
| (verify) | |
Use and effects
The dose range of 5-MeO-αET is 50 to 75 mg orally.[1][additional citation(s) needed] 5-MeO-αET produces entactogenic and stimulant effects that can last 4 to 6 hours.[citation needed] However, little information exists on the psychopharmacological effects of this compound, thus considerable variation with regard to dose and effects can be expected.[citation needed]
Interactions
Pharmacology
Pharmacodynamics
The pharmacology of 5-MeO-αET has been studied.[3] It is a weak partial agonist of the serotonin 5-HT2A receptor, with a binding affinity (Ki) of 4,073 nM, an EC50 of 166 nM, and an Emax of 34%.[3] For comparison, αET showed 14-fold lower affinity for the receptor than 5-MeO-αET and was inactive as an agonist of the receptor.[3] The individual stereoisomers of 5-MeO-αET and αET were also assessed.[3]
Chemistry
Analogues
Analogues of 5-MeO-AET include α-ethyltryptamine (AET), α-methylserotonin (5-HO-AMT), 5-MeO-AMT, 4-methyl-AET, 5-fluoro-AET, 5-EtO-AMT, 5-fluoro-AET, 5-chloro-AET, and 7-methyl-AET, among others.
Society and culture
Legal status
Canada
5-MeO-AET is not a controlled substance in Canada as of 2025.[4]
United States
5-MeO-αET is unscheduled and uncontrolled in the United States, but possession and sales of 5-MeO-αET could be prosecuted under the Federal Analog Act because of its structural similarities to αET and αMT.[citation needed]