6-APT

6-(2-Aminopropyl)tetralin (6-APT), also sometimes called tetralinylaminopropane (TAP), is a drug of the amphetamine class which acts as a selective serotonin releasing agent (SSRA).^[1] It has IC₅₀ values of 121 nM, 6,436 nM, and 3,371 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively.^[1] Though it possesses an appreciable in vitro profile, in animal drug discrimination studies it was not found to substitute for MMAI or amphetamine and to only partially substitute for MBDB.^[1] This parallels Alexander Shulgin's finding that EDMA (the 1,4-benzodioxine analogue of 6-APT) is limitedly active,^[2] and appears to indicate that the pharmacokinetics of both EDMA and 6-APT may not be favorable.^[1]

Routes of
administrationOral

ATC code

• none

Legal status

• Uncontrolled (but may be covered under the Federal Analogue Act in the United States and under similar bills in other countries)

CAS Number

• 3160-20-1

Quick facts Clinical data, Routes ofadministration ...

6-APT

Clinical data
Routes of administration	Oral
ATC code	none
Legal status
Legal status	Uncontrolled (but may be covered under the Federal Analogue Act in the United States and under similar bills in other countries)
Identifiers
IUPAC name 1-(5,6,7,8-Tetrahydronaphthalen-2-yl)propan-2-amine
CAS Number	3160-20-1
PubChem CID	14964398
ChemSpider	23204045 Y
UNII	F26UB8P44X
ChEMBL	ChEMBL331488
CompTox Dashboard (EPA)	DTXSID201029471
Chemical and physical data
Formula	C13H19N
Molar mass	189.302 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(CC1=CC2=C(CCCC2)C=C1)N
InChI InChI=1S/C13H19N/c1-10(14)8-11-6-7-12-4-2-3-5-13(12)9-11/h6-7,9-10H,2-5,8,14H2,1H3 Y Key:UTVKUFYOPJCDPE-UHFFFAOYSA-N Y
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