6-Fluoro-DMT

6-Fluoro-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).^[3] However, he did briefly discuss it in an early literature review, but its properties and effects in humans were not described.^[1]

The closely related compound 6-fluoro-DET has been found to be inactive in terms of psychedelic-type effects both in animals and humans.^{[4][5][6][3][7]} Relatedly, it has been claimed that 6-fluoro-DMT is inactive as a psychedelic similarly to 6-fluoro-DET, though it is unclear whether this claim was based on actual testing or on extrapolation from 6-fluoro-DET and theoretical notions.^[8] In the 1960s, it had been theorized by Stephen Szára and colleagues that psychedelic tryptamines were prodrugs that required 6-hydroxylation to become hallucinogenic, but this theory was later found to be incorrect.^{[9][10][11][12]}

Indeed, the related compound 6-fluoro-AMT is known to be robustly active as a psychedelic.^[13][14] Additionally, 6-fluoro-DMT robustly induces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.^[15][16] Likewise, HBL20016 (5-MeS-6-F-DMT), the 5-methylthio derivative of 6-fluoro-DMT, robustly produces the head-twitch response in rodents as well.^[17][18]

6-Fluoro-DMT was first described in the scientific literature by at least 1966.^[1][20][8]

• Substituted tryptamine
• Non-hallucinogenic 5-HT_2A receptor agonist