6-Methyl-DMT
Pharmaceutical compound
From Wikipedia, the free encyclopedia
6-Methyl-DMT, or 6-Me-DMT, also known as 6-methyl-N,N-dimethyltryptamine or as 6,N,N-trimethyltryptamine (6,N,N-TMT or 6-TMT), is a serotonin receptor modulator of the tryptamine family related to dimethyltryptamine (DMT).[1][2] It is the 6-methyl derivative of DMT.[1][2]
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| Other names | 6-Me-DMT; 6-Methyl-N,N-dimethyltryptamine; 6,N,N-Trimethyltryptamine; 6,N,N-TMT; 6-TMT |
| Drug class | Serotonin receptor modulator |
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| Formula | C13H18N2 |
| Molar mass | 202.301 g·mol−1 |
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Use and effects
6-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[3]
Pharmacology
Pharmacodynamics
6-Methyl-DMT showed about half the affinity of DMT for the ketanserin-labeled serotonin 5-HT2 receptor (Ki = 2,500 nM and 1,200 nM, respectively).[1][4] The drug did not substitute for 5-MeO-DMT in rodent drug discrimination tests.[2] According to David E. Nichols, 6-substituted tryptamines in general may be inactive as serotonergic psychedelics.[5] However, 6-fluoro-AMT is known to be robustly active as a psychedelic.[6][7]
Chemistry
Synthesis
The chemical synthesis of 6-methyl-DMT has been described.[2]
Analogues
Analogues of 6-methyl-DMT include 6-methyltryptamine, dimethyltryptamine (DMT), 6-MeO-DMT, 6-MeO-DiPT, 6-MeO-MiPT, 6-hydroxy-DMT, 6-hydroxy-DET, 6-fluoro-DMT, 6-fluoro-DET, 6-fluoro-AMT, O-4310 (1-iPr-6-F-4-HO-DMT), 1-methyl-DMT, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, and 7-methyl-DMT, among others.[3]
History
6-Methyl-DMT was first described in the scientific literature by Richard Glennon and colleagues by 1980.[2]