6-Fluoronorepinephrine

6-Fluoronorepinephrine
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol;
CAS Number	86820-21-5 ;
PubChem CID	1862;
IUPHAR/BPS	510;
ChemSpider	1792 ;
ChEMBL	ChEMBL281232 ;
CompTox Dashboard (EPA)	DTXSID301007133 ;
Chemical and physical data
Formula	C8H10FNO3
Molar mass	187.170 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1cc(O)c(O)cc1C(O)CN;
	InChI InChI=1S/C8H10FNO3/c9-5-2-7(12)6(11)1-4(5)8(13)3-10/h1-2,8,11-13H,3,10H2 ; Key:SBUQBFTXTZSRMH-UHFFFAOYSA-N ;
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6-Fluoronorepinephrine (6-FNE) is a selective α₁- and α₂-adrenergic receptor full agonist related to norepinephrine.^[1]^[2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.^[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α₁-adrenergic receptors.^[2]^[3]