6-carboxytetrahydropterin synthase

6-carboxytetrahydropterin synthase (EC 4.1.2.50, CPH4 synthase, queD (gene), ToyB, ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming).^[1][2] This enzyme catalyses the following reversible chemical reaction.

7,8-dihydroneopterin 3′-triphosphate + H₂O ⇌ 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

EC no.4.1.2.50

BRENDAenzyme data

ExPASyNiceZyme view

KEGGenzyme entry

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6-carboxytetrahydropterin synthase
6-Carboxy-5,6,7,8-tetrahydropterin synthase hexamer, E.Coli
Identifiers
EC no.	4.1.2.50
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
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This enzyme binds Zn²⁺. It is isolated from the bacteria Bacillus subtilis and Escherichia coli. The stimulation is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin.^[2]