60S ribosomal protein L4

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.^[5][6][7]

AliasesRPL4, L4, Ribosomal protein L4

External IDsOMIM: 180479; MGI: 1915141; GeneCards: RPL4

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 15 (human)^[1]

Quick facts RPL4, Identifiers ...

RPL4
Identifiers
Aliases	RPL4, L4, Ribosomal protein L4
External IDs	OMIM: 180479; MGI: 1915141; GeneCards: RPL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 5A8L, 4D67, 4D5Y, 4UJE, 4UJC
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 66,498,015 bp[1] End 66,524,532 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 64,080,657 bp[2] End 64,085,948 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in embryo ganglionic eminence cartilage tissue ventricular zone vulva tail of epididymis glutes smooth muscle tissue superficial temporal artery caput epididymis Top expressed in tail of embryo genital tubercle epiblast ovary blastocyst ventricular zone ganglionic eminence uterus embryo urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding Cellular component cytoplasm cytosol ribosome membrane focal adhesion nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus rough endoplasmic reticulum ribonucleoprotein complex Biological process protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6124 67891 Ensembl ENSG00000174444 ENSMUSG00000032399 UniProt P36578 Q9D8E6 RefSeq (mRNA) NM_000968 NM_024212 RefSeq (protein) NP_000959 NP_077174 Location (UCSC) Chr 15: 66.5 – 66.52 Mb Chr 9: 64.08 – 64.09 Mb PubMed search [3] [4]
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]