8-Hydroxyamoxapine

8-Hydroxyamoxapine
Pharmacokinetic data
Elimination half-life	30 hours
Identifiers
	IUPAC name 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepin-3-ol;
CAS Number	61443-78-5;
PubChem CID	43656;
ChemSpider	39784;
UNII	0D4T741I48;
ChEBI	CHEBI:143289;
CompTox Dashboard (EPA)	DTXSID40210388;
Chemical and physical data
Formula	C17H16ClN3O2
Molar mass	329.78 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCN1)C2=NC3=C(C=CC(=C3)O)OC4=C2C=C(C=C4)Cl;
	InChI InChI=1S/C17H16ClN3O2/c18-11-1-3-15-13(9-11)17(21-7-5-19-6-8-21)20-14-10-12(22)2-4-16(14)23-15/h1-4,9-10,19,22H,5-8H2; Key:QDWNOKXUZTYVGO-UHFFFAOYSA-N;

8-Hydroxyamoxapine is an active metabolite of the antidepressant drug amoxapine (Asendin). It contributes to amoxapine's pharmacology.^[1]^[2] It is a serotonin-norepinephrine reuptake inhibitor (SNRI) with similar norepinephrine, but more serotonin, reuptake inhibition as its parent compound. It plays a part in balancing amoxapine's ratio of serotonin to norepinephrine transporter blockage.^[3]