8-hydroxyquercetin 8-O-methyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
8-hydroxyquercetin 8-O-methyltransferase (EC 2.1.1.88) is an enzyme that catalyzes the chemical reaction
| 8-hydroxyquercitin 8-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.88 | ||||||||
| CAS no. | 99775-17-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This is a methylation reaction in which the flavonol, gossypetin, is converted to the O-methylated flavonoid corniculatusin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The product takes its name from the plant Lotus corniculatus in which it is found.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3,5,7,8,3',4'-hexahydroxyflavone 8-O-methyltransferase. Other names in common use include flavonol 8-O-methyltransferase, flavonol 8-methyltransferase, S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone, 8-O-methyltransferase, and 8-hydroxyquercitin 8-O-methyltransferase [mis-spelt].[2]
