A4GALT

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.^[5][6]

AliasesA4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)

External IDsOMIM: 607922; MGI: 3512453; HomoloGene: 9690; GeneCards: A4GALT; OMA:A4GALT - orthologs

EC number2.4.1.228

Chr.Chromosome 22 (human)^[1]

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A4GALT
Identifiers
Aliases	A4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)
External IDs	OMIM: 607922; MGI: 3512453; HomoloGene: 9690; GeneCards: A4GALT; OMA:A4GALT - orthologs
EC number	2.4.1.228
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 42,692,121 bp[1] End 42,721,298 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,110,923 bp[2] End 83,135,975 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart olfactory zone of nasal mucosa right auricle of heart gastric mucosa tibial nerve left ventricle thoracic aorta ascending aorta popliteal artery tibial arteries Top expressed in decidua seminal vesicula interventricular septum choroid plexus of fourth ventricle cardiac muscle tissue of left ventricle entorhinal cortex plantaris muscle extensor digitorum longus muscle corneal stroma zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity lactosylceramide 4-alpha-galactosyltransferase activity galactosyltransferase activity toxic substance binding glycosyltransferase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi membrane Golgi apparatus membrane Biological process glycosphingolipid biosynthetic process globoside biosynthetic process protein glycosylation plasma membrane organization lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53947 239559 Ensembl ENSG00000128274 ENSMUSG00000047878 UniProt Q9NPC4 Q67BJ4 RefSeq (mRNA) NM_017436 NM_001318038 NM_001004150 NM_001170954 NM_001370647 RefSeq (protein) NP_001304967 NP_059132 NP_001004150 NP_001164425 NP_001357576 Location (UCSC) Chr 22: 42.69 – 42.72 Mb Chr 15: 83.11 – 83.14 Mb PubMed search [3] [4]
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The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.^[6]