AB-005

AB-005 or [1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone is a designer drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (K_i = 5.5 nM) and CB2 receptors (K_i = 0.48 nM).^[1] AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group of UR-144 and XLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent of AM-1248 and AM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans.

Legal status

• CA: Schedule II
• DE: NpSG (Industrial and scientific use only)
• UK: Class B

CAS Number

• 895155-25-6 ^Y

PubChem CID

• 11537652

ChemSpider

• 9712433

Quick facts Legal status, Identifiers ...

AB-005

Legal status
Legal status	CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B
Identifiers
IUPAC name [1-[(1-Methylpiperidin-2-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
CAS Number	895155-25-6 Y
PubChem CID	11537652
ChemSpider	9712433
UNII	TPY5M47AYQ
ChEMBL	ChEMBL571330
CompTox Dashboard (EPA)	DTXSID001017492
Chemical and physical data
Formula	C23H32N2O
Molar mass	352.522 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(C(C1(C)C)C(=O)C2=CN(C3=CC=CC=C32)CC4CCCCN4C)C
InChI InChI=1S/C23H32N2O/c1-22(2)21(23(22,3)4)20(26)18-15-25(19-12-7-6-11-17(18)19)14-16-10-8-9-13-24(16)5/h6-7,11-12,15-16,21H,8-10,13-14H2,1-5H3 Key:MOBWRRIAIHYXLB-UHFFFAOYSA-N

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