AB-PINACA

AB-PINACA is a compound that was first identified as a component of synthetic cannabis products in Japan in 2012.^[2]

Legal status

• BR: Class F2 (Prohibited psychotropics)^[1]
• CA: Schedule II
• DE: Anlage II (Authorized trade only, not prescriptible)
• UK: Class B
• US: Schedule I

CAS Number

• 1445752-09-9 ^Y

PubChem CID

• 71301472

ChemSpider

• 28537615

Quick facts Legal status, Identifiers ...

AB-PINACA

Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B US: Schedule I
Identifiers
IUPAC name N-[(1S)-1-(Aminocarbonyl)-2-methylpropyl]-1-pentyl-1H-indazole-3-carboxamide
CAS Number	1445752-09-9 Y
PubChem CID	71301472
ChemSpider	28537615
UNII	6J3KC3S2PA
KEGG	C22704
CompTox Dashboard (EPA)	DTXSID00904034
Chemical and physical data
Formula	C18H26N4O2
Molar mass	330.432 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCn1c2ccccc2c(n1)C(=O)N[C@@H](C(C)C)C(=O)N
InChI InChI=1S/C18H26N4O2/c1-4-5-8-11-22-14-10-7-6-9-13(14)16(21-22)18(24)20-15(12(2)3)17(19)23/h6-7,9-10,12,15H,4-5,8,11H2,1-3H3,(H2,19,23)(H,20,24)/t15-/m0/s1 Key:GIMHPAQOAAZSHS-HNNXBMFYSA-N

Close

It was originally developed by Pfizer in 2009 as an analgesic medication.^[3][4]

AB-PINACA acts as a potent agonist for the CB₁ receptor (K_i = 2.87 nM, EC₅₀ = 1.2 nM) and CB₂ receptor (K_i = 0.88 nM, EC₅₀ = 2.5 nM) and fully substitutes for Δ⁹-THC in rat discrimination studies, while being 1.5x more potent.^[5][6]

There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.^[7][8]