ABCC4

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.^[5][6]

AliasesABCC4, MOAT-B, MOATB, MRP4, ATP binding cassette subfamily C member 4

External IDsOMIM: 605250; MGI: 2443111; HomoloGene: 74563; GeneCards: ABCC4; OMA:ABCC4 - orthologs

Chr.Chromosome 13 (human)^[1]

End95,301,475 bp^[1]

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ABCC4
Identifiers
Aliases	ABCC4, MOAT-B, MOATB, MRP4, ATP binding cassette subfamily C member 4
External IDs	OMIM: 605250; MGI: 2443111; HomoloGene: 74563; GeneCards: ABCC4; OMA:ABCC4 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.1 Start 95,019,835 bp[1] End 95,301,475 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 118,720,104 bp[2] End 118,943,631 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva secondary oocyte buccal mucosa cell corpus epididymis kidney tubule mucosa of urinary bladder Epithelium of choroid plexus epithelium of nasopharynx mucosa of sigmoid colon stromal cell of endometrium Top expressed in transitional epithelium of urinary bladder conjunctival fornix Epithelium of choroid plexus olfactory epithelium lacrimal gland iris ciliary body retinal pigment epithelium cornea lumbar spinal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding 15-hydroxyprostaglandin dehydrogenase (NAD+) activity ATPase-coupled inorganic anion transmembrane transporter activity P-type ion transporter activity ATPase-coupled transmembrane transporter activity protein binding Cellular component integral component of membrane platelet dense granule membrane membrane plasma membrane basolateral plasma membrane integral component of plasma membrane Biological process prostaglandin secretion platelet degranulation response to organic cyclic compound response to organic substance positive regulation of smooth muscle cell proliferation response to organonitrogen compound transmembrane transport cilium assembly transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10257 239273 Ensembl ENSG00000125257 ENSMUSG00000032849 UniProt O15439 E9Q236 RefSeq (mRNA) NM_001105515 NM_001301829 NM_001301830 NM_005845 NM_001033336 NM_001163675 NM_001163676 RefSeq (protein) NP_001098985 NP_001288758 NP_001288759 NP_005836 NP_001028508 NP_001157147 NP_001157148 Location (UCSC) Chr 13: 95.02 – 95.3 Mb Chr 14: 118.72 – 118.94 Mb PubMed search [3] [4]
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ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.^[7] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.^[8]

MRP4/ABCC4 expression is dysregulated in several cancers ^[9][10][11] and is also upregulated in peritoneal endometriosis.^[12]