ABRA (gene)

AliasesABRA, STARS, actin binding Rho activating protein

External IDsOMIM: 609747; MGI: 2444891; HomoloGene: 34713; GeneCards: ABRA; OMA:ABRA - orthologs

Chr.Chromosome 8 (human)^[1]

End106,770,244 bp^[1]

ABRA
Identifiers
Aliases	ABRA, STARS, actin binding Rho activating protein
External IDs	OMIM: 609747; MGI: 2444891; HomoloGene: 34713; GeneCards: ABRA; OMA:ABRA - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.1 Start 106,759,483 bp[1] End 106,770,244 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 41,727,472 bp[2] End 41,733,116 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii quadriceps femoris muscle vastus lateralis muscle deltoid muscle right ventricle muscle of thigh gastrocnemius muscle myocardium body of tongue Top expressed in interventricular septum muscle of thigh soleus muscle knee joint extraocular muscle quadriceps femoris muscle vastus lateralis muscle digastric muscle tibialis anterior muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding Cellular component cytoplasm plasma membrane sarcomere myofibril cytoskeleton actin cytoskeleton Biological process positive regulation of Rho protein signal transduction protein transport positive regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 137735 223513 Ensembl ENSG00000174429 ENSMUSG00000042895 UniProt Q8N0Z2 Q8BUZ1 RefSeq (mRNA) NM_139166 NM_175456 RefSeq (protein) NP_631905 NP_780665 Location (UCSC) Chr 8: 106.76 – 106.77 Mb Chr 15: 41.73 – 41.73 Mb PubMed search [3] [4]
Wikidata
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Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene.^[5] The mouse and rat homologues are known as STARS (striated muscle activator of Rho signalling) and MS1 (myocyte stress 1) respectively.^[6]

MS1/STARS is regulated by MyoD during myogenic differentiation of the C2C12 cell line.