ACER3

ACER3
Identifiers
Aliases	ACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO
External IDs	OMIM: 617036; MGI: 1913440; GeneCards: ACER3
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,026,797 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,321,208 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; inferior ganglion of vagus nerve; ; mucosa of ileum; ; corpus callosum; ; pancreatic epithelial cell; ; pars reticulata; ; pars compacta; ; Brodmann area 46; ; subthalamic nucleus; ; buccal mucosa cell;
	Top expressed in
	conjunctival fornix; ; cornea; ; interventricular septum; ; hair follicle; ; skin of external ear; ; sciatic nerve; ; decidua; ; skin of back; ; lobe of prostate; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; phytoceramidase activity; N-acylsphingosine amidohydrolase activity; dihydroceramidase activity; ceramidase activity; calcium ion binding; zinc ion binding; metal ion binding;
Cellular component	integral component of membrane; integral component of Golgi membrane; integral component of endoplasmic reticulum membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	sphingosine biosynthetic process; sphingolipid biosynthetic process; phytosphingosine biosynthetic process; ceramide metabolic process; positive regulation of cell population proliferation; inflammatory response; myelination; regulation of programmed cell death; ceramide catabolic process; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55331
	66190
	ENSG00000078124
	ENSMUSG00000030760
	Q9NUN7
	Q9D099
	NM_001300953; NM_001300954; NM_001300955; NM_018367
	NM_025408
	NP_001287882; NP_001287883; NP_001287884; NP_060837
	NP_079684; NP_001347544; NP_001347545; NP_001347546
	Wikidata
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