AGK2 (SIRT2 inhibitor)

Drug classSirtuin 2 (SIRT2) inhibitor

CAS Number

• 304896-28-4

PubChem CID

• 2130404

IUPHAR/BPS

• 8099

AGK2 (SIRT2 inhibitor)

Clinical data
Drug class	Sirtuin 2 (SIRT2) inhibitor
Identifiers
IUPAC name (E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide
CAS Number	304896-28-4
PubChem CID	2130404
IUPHAR/BPS	8099
ChemSpider	1596332
UNII	DDF0L8606A
ChEBI	CHEBI:94578
ChEMBL	ChEMBL224864
CompTox Dashboard (EPA)	DTXSID80184559
ECHA InfoCard	100.164.349
Chemical and physical data
Formula	C23H13Cl2N3O2
Molar mass	434.28 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC2=C(C=CC=N2)C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N
InChI InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+ Key:SVENPFFEMUOOGK-SDNWHVSQSA-N

AGK2 is a drug which acts as a selective sirtuin 2 (SIRT2) inhibitor. It was one of the first selective SIRT2 inhibitors developed,^[1] and inhibits SIRT2 with an IC₅₀ of 3.5μM, making it less potent than other more recently developed compounds, but it is still widely used in research. It has good selectivity for SIRT2 over SIRT1 and SIRT3, though its activity at other subtypes is less well characterised. It has antiviral effects,^[2][3] and has been used to study the potential role of SIRT2 inhibitors for the treatment of Parkinson’s disease as well cardiac fibrosis,^[4] and some forms of cancer.^[5][6][7][8]