AGPAT1

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme encoded by the AGPAT1 gene in humans.^[5][6][7]

AliasesAGPAT1, 1-G15, LPAAT-alpha, LPAATA, 1-acylglycerol-3-phosphate O-acyltransferase 1

External IDsOMIM: 603099; MGI: 1932075; HomoloGene: 55973; GeneCards: AGPAT1; OMA:AGPAT1 - orthologs

Chr.Chromosome 6 (human)^[1]

End32,178,096 bp^[1]

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AGPAT1
Identifiers
Aliases	AGPAT1, 1-G15, LPAAT-alpha, LPAATA, 1-acylglycerol-3-phosphate O-acyltransferase 1
External IDs	OMIM: 603099; MGI: 1932075; HomoloGene: 55973; GeneCards: AGPAT1; OMA:AGPAT1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,168,212 bp[1] End 32,178,096 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.18 cM Start 34,823,236 bp[2] End 34,832,423 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe superior frontal gyrus left testis right testis anterior cingulate cortex primary visual cortex stromal cell of endometrium hippocampus proper dorsolateral prefrontal cortex nucleus accumbens Top expressed in spermatid spermatocyte endocardial cushion muscle of thigh superior frontal gyrus yolk sac primary visual cortex atrioventricular valve dentate gyrus of hippocampal formation granule cell granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity protein binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process positive regulation of cytokine-mediated signaling pathway positive regulation of cytokine production lipid metabolism phospholipid biosynthetic process phospholipid metabolic process metabolism positive regulation of cellular metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10554 55979 Ensembl ENSG00000236873 ENSG00000235758 ENSG00000228892 ENSG00000204310 ENSG00000226467 ENSG00000227642 ENSG00000206324 ENSMUSG00000034254 UniProt Q99943 O35083 RefSeq (mRNA) NM_006411 NM_032741 NM_001371437 NM_001371438 NM_001371439 NM_001163379 NM_018862 RefSeq (protein) NP_006402 NP_116130 NP_001358366 NP_001358367 NP_001358368 NP_001156851 NP_061350 Location (UCSC) Chr 6: 32.17 – 32.18 Mb Chr 17: 34.82 – 34.83 Mb PubMed search [3] [4]
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This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). Both LPA and PA are phospholipids involved in signal transduction and in lipid biosynthesis within cells. The enzyme is localized in the endoplasmic reticulum. The gene is situated in the class III region of the human major histocompatibility complex (MHC). Alternative splicing of this gene results in two transcript variants, both of which encode the same protein.^[7]