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ALX-1393

Glycine reuptake inhibitor From Wikipedia, the free encyclopedia

ALX-1393 is a glycine reuptake inhibitor.

Quick facts Names, Identifiers ...
ALX-1393[1]
Names
IUPAC name
(2S)-2-Amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1
    Key: ADUSZEGHFWRTQS-AIBWNMTMSA-N
  • C1=CC=C(C=C1)COC2=CC=CC=C2C(C3=CC(=CC=C3)F)OCC(C(=O)O)N
Properties
C23H22FNO4
Molar mass 395.430 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pharmacodynamics

ALX-1393 works by inhibiting the action of GLYT2.[2] This causes elevated levels of glycine, an inhibitory neurotransmitter.

Potential uses

ALX-1393 has been shown to have potential as an analgesic. This is thought to be due to the elevated glycine levels reducing the transmission of the pain signals.[3]

Tests have shown that it was able to help reduce cancer pain in a potent way.[4]

References

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