ANTXR1

Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene.^[5][6][7] Its molecular weight is predicted as about 63kDa.

PDBOrtholog search: PDBe RCSB

AliasesANTXR1, ATR, GAPO, TEM8, anthrax toxin receptor 1, ANTXR cell adhesion molecule 1

External IDsOMIM: 606410; MGI: 1916788; HomoloGene: 12976; GeneCards: ANTXR1; OMA:ANTXR1 - orthologs

Chr.Chromosome 2 (human)^[1]

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ANTXR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N2N
Identifiers
Aliases	ANTXR1, ATR, GAPO, TEM8, anthrax toxin receptor 1, ANTXR cell adhesion molecule 1
External IDs	OMIM: 606410; MGI: 1916788; HomoloGene: 12976; GeneCards: ANTXR1; OMA:ANTXR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 69,013,176 bp[1] End 69,249,327 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 87,110,835 bp[2] End 87,312,803 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium decidua palpebral conjunctiva saphenous vein vena cava tendon of biceps brachii right coronary artery synovial joint pericardium urethra Top expressed in median eminence epithelium of lens body of femur cornea gastrula condyle molar umbilical cord fossa efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding protein binding collagen binding transmembrane signaling receptor activity metal ion binding signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane cell projection endosome membrane lamellipodium membrane extracellular exosome membrane filopodium membrane external side of plasma membrane Biological process actin cytoskeleton reorganization reproductive process substrate adhesion-dependent cell spreading signal transduction positive regulation of metallopeptidase activity negative regulation of extracellular matrix assembly blood vessel development toxin transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84168 69538 Ensembl ENSG00000169604 ENSMUSG00000033420 UniProt Q9H6X2 Q96EC6 Q9CZ52 RefSeq (mRNA) NM_018153 NM_032208 NM_053034 NM_054041 RefSeq (protein) NP_060623 NP_115584 NP_444262 NP_060623.2 NP_473382 Location (UCSC) Chr 2: 69.01 – 69.25 Mb Chr 6: 87.11 – 87.31 Mb PubMed search [3] [4]
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The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.^[7]