APOLD1

Apolipoprotein L domain containing 1 is a protein in humans that is encoded by the APOLD1 gene. ^[5] It is located on Chromosome 12.^[6]

AliasesAPOLD1, VERGE, apolipoprotein L domain containing 1

External IDsOMIM: 612456; MGI: 2685921; HomoloGene: 12781; GeneCards: APOLD1; OMA:APOLD1 - orthologs

Chr.Chromosome 12 (human)^[1]

End12,829,975 bp^[1]

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APOLD1
Identifiers
Aliases	APOLD1, VERGE, apolipoprotein L domain containing 1
External IDs	OMIM: 612456; MGI: 2685921; HomoloGene: 12781; GeneCards: APOLD1; OMA:APOLD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 12,725,917 bp[1] End 12,829,975 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 134,958,681 bp[2] End 134,963,799 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pericardium thoracic diaphragm lower lobe of lung mucosa of urinary bladder subcutaneous adipose tissue Epithelium of choroid plexus left uterine tube olfactory bulb inferior olivary nucleus Top expressed in endothelial cell of lymphatic vessel semi-lunar valve retinal pigment epithelium aortic valve islet of Langerhans spermatocyte olfactory bulb ascending aorta atrioventricular valve brown adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function lipid binding Cellular component extracellular region plasma membrane integral component of membrane membrane nucleoplasm cytosol Biological process angiogenesis response to hypoxia lipid transport cell differentiation endothelial cell activation lipoprotein metabolic process regulation of endothelial cell differentiation multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81575 381823 Ensembl ENSG00000178878 ENSMUSG00000090698 UniProt Q96LR9 E9Q0X2 RefSeq (mRNA) NM_030817 NM_001130415 NM_001109914 RefSeq (protein) NP_001123887 NP_110444 NP_001103384 Location (UCSC) Chr 12: 12.73 – 12.83 Mb Chr 6: 134.96 – 134.96 Mb PubMed search [3] [4]
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APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008].