APPBP2

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.^[5][6]

AliasesAPPBP2, APP-BP2, HS.84084, PAT1, amyloid beta precursor protein binding protein 2

External IDsOMIM: 605324; MGI: 1914134; HomoloGene: 31378; GeneCards: APPBP2; OMA:APPBP2 - orthologs

Chr.Chromosome 17 (human)^[1]

End60,526,242 bp^[1]

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APPBP2
Identifiers
Aliases	APPBP2, APP-BP2, HS.84084, PAT1, amyloid beta precursor protein binding protein 2
External IDs	OMIM: 605324; MGI: 1914134; HomoloGene: 31378; GeneCards: APPBP2; OMA:APPBP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.2 Start 60,443,158 bp[1] End 60,526,242 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 85,078,088 bp[2] End 85,125,956 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 lateral nuclear group of thalamus cerebellar vermis pars compacta pars reticulata buccal mucosa cell dorsal motor nucleus of vagus nerve external globus pallidus internal globus pallidus Top expressed in Rostral migratory stream vas deferens Gonadal ridge abdominal wall umbilical cord efferent ductule epithelium of lens migratory enteric neural crest cell ventromedial nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity protein binding Cellular component microtubule cytoskeleton cytoplasmic vesicle membrane membrane nucleus microtubule associated complex cytoplasm Biological process protein transport intracellular transport intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10513 66884 Ensembl ENSG00000062725 ENSMUSG00000018481 UniProt Q92624 Q9DAX9 RefSeq (mRNA) NM_001282476 NM_006380 NM_025825 RefSeq (protein) NP_001269405 NP_006371 NP_080101 Location (UCSC) Chr 17: 60.44 – 60.53 Mb Chr 11: 85.08 – 85.13 Mb PubMed search [3] [4]
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The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.^[6]