AR420626

Pharmaceutical compound From Wikipedia, the free encyclopedia

AR420626 is an experimental drug which acts as a reasonably potent and highly selective agonist for the free fatty acid receptor FFAR3 (GPR41).[1][2] It has been used to research the role of FFAR3 in various disease processes such as diabetes,[3] asthma,[4] eczema[4] and some forms of cancer,[5] as well as regulation of gastrointestinal hormone release.[6]

CAS Number
PubChem CID
ChemSpider
ChEMBL
Quick facts Identifiers, CAS Number ...
AR420626
Identifiers
  • N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC21H18Cl2N2O3
Molar mass417.29 g·mol−1
3D model (JSmol)
  • CC1=C(C(C2=C(N1)CCCC2=O)C3=CC=CO3)C(=O)NC4=C(C=CC(=C4)Cl)Cl
  • InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
  • Key:GGTYQECCGLBHGS-UHFFFAOYSA-N
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Further reading

  • Said H, Akiba Y, Narimatsu K, Maruta K, Kuri A, Iwamoto KI, et al. (August 2017). "FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats". Digestive Diseases and Sciences. 62 (8): 1944–1952. doi:10.1007/s10620-017-4600-4. PMC 5511769. PMID 28523577.
  • Yoshioka Y, Tachibana Y, Uesaka T, Hioki H, Sato Y, Fukumoto T, et al. (June 2022). "Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin". Biochemical and Biophysical Research Communications. 608: 66–72. Bibcode:2022BBRC..608...66Y. doi:10.1016/j.bbrc.2022.03.117. hdl:20.500.14094/90009216. PMID 35390674.

References

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