ARHGAP29

From Wikipedia, the free encyclopedia

AliasesARHGAP29, PARG1, Rho GTPase activating protein 29
End94,275,068 bp[1]
ARHGAP29
Identifiers
AliasesARHGAP29, PARG1, Rho GTPase activating protein 29
External IDsOMIM: 610496; MGI: 2443818; HomoloGene: 3539; GeneCards: ARHGAP29; OMA:ARHGAP29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004815
NM_001328664
NM_001328665
NM_001328666
NM_001328667

NM_172525
NM_001356524

RefSeq (protein)

NP_001315593
NP_001315594
NP_001315595
NP_001315596
NP_004806

NP_766113
NP_001343453

Location (UCSC)Chr 1: 94.15 – 94.28 MbChr 3: 121.75 – 121.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ARHGAP29 is a gene located on chromosome 1p22 that encodes Rho GTPase activating protein (GAP) 29,[5] a protein that mediates the cyclical regulation of small GTP binding proteins such as RhoA.[6]

ARHGAP29 is expressed in the developing face and may act downstream of IRF6 in craniofacial development.[7]

Structure

ARHGAP29 contains four domains including a coiled-coil region known to interact with Rap2,[8] a C1 domain, the Rho GTPase domain, and a small C-terminal region that interacts with PTPL1.[6]

Clinical significance

References

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