ARIH2
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Protein ariadne-2 homolog is a protein that is encoded by the ARIH2 gene in humans.[4][5]
External IDsOMIM: 605615; MGI: 1344361; HomoloGene: 48424; GeneCards: ARIH2; OMA:ARIH2 - orthologs
Function
ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulates the proliferation,[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.[8]