ARIH2

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Protein ariadne-2 homolog is a protein that is encoded by the ARIH2 gene in humans.[4][5]

AliasesARIH2, ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
Chr.Chromosome 9 (mouse)[1]
End108,526,585 bp[1]
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ARIH2
Identifiers
AliasesARIH2, ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
External IDsOMIM: 605615; MGI: 1344361; HomoloGene: 48424; GeneCards: ARIH2; OMA:ARIH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006321
NM_001317333
NM_001317334

NM_011790
NM_001357283
NM_001357285
NM_001357286

RefSeq (protein)

NP_035920
NP_001344212
NP_001344214
NP_001344215

Location (UCSC)n/aChr 9: 108.48 – 108.53 Mb
PubMed search[2][3]
Wikidata
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Function

ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulates the proliferation,[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.[8]

References

Further reading

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