ARNT2

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.^[5][6]

AliasesARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2

External IDsOMIM: 606036; MGI: 107188; HomoloGene: 7230; GeneCards: ARNT2; OMA:ARNT2 - orthologs

Chr.Chromosome 15 (human)^[1]

End80,597,933 bp^[1]

Quick facts Identifiers, Aliases ...

ARNT2
Identifiers
Aliases	ARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDs	OMIM: 606036; MGI: 107188; HomoloGene: 7230; GeneCards: ARNT2; OMA:ARNT2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 80,404,350 bp[1] End 80,597,933 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D3|7 48.35 cM Start 83,895,486 bp[2] End 84,059,384 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus middle temporal gyrus frontal pole middle frontal gyrus Brodmann area 10 entorhinal cortex optic nerve superior vestibular nucleus parietal lobe ventral tegmental area Top expressed in subiculum superior frontal gyrus paraventricular nucleus of hypothalamus globus pallidus nucleus accumbens dorsal tegmental nucleus dorsomedial hypothalamic nucleus ganglionic eminence ventral tegmental area dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity aryl hydrocarbon receptor binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex nucleus nucleoplasm Biological process response to estradiol response to hypoxia regulation of transcription, DNA-templated negative regulation of apoptotic process in utero embryonic development transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated central nervous system development brain development positive regulation of cell population proliferation xenobiotic metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9915 11864 Ensembl ENSG00000172379 ENSMUSG00000015709 UniProt Q9HBZ2 Q61324 RefSeq (mRNA) NM_014862 NM_007488 RefSeq (protein) NP_055677 NP_055677.3 NP_031514 Location (UCSC) Chr 15: 80.4 – 80.6 Mb Chr 7: 83.9 – 84.06 Mb PubMed search [3] [4]
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This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.^[6]