ART26.12

ART26.12
Identifiers
	IUPAC name (2R,4R)-3-(2,3-dihydro-1H-inden-2-yloxycarbonyl)-2,4-bis(2-methoxyphenyl)cyclobutane-1-carboxylic acid;
CAS Number	2766800-24-0;
PubChem CID	163249803;
Chemical and physical data
Formula	C29H28O6
Molar mass	472.537 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC=CC=C1[C@@H]2C([C@H](C2C(=O)OC3CC4=CC=CC=C4C3)C5=CC=CC=C5OC)C(=O)O;
	InChI InChI=1S/C29H28O6/c1-33-22-13-7-5-11-20(22)24-26(28(30)31)25(21-12-6-8-14-23(21)34-2)27(24)29(32)35-19-15-17-9-3-4-10-18(17)16-19/h3-14,19,24-27H,15-16H2,1-2H3,(H,30,31)/t24-,25-,26?,27?/m1/s1; Key:HFKXLDACQCGGEI-BINWOUKTSA-N;

ART26.12 is an experimental drug that acts as a selective inhibitor of the enzyme FABP5, which usually breaks down endocannabinoids such as anandamide. ART26.12 thereby boosts endocannabinoid levels and has analgesic effects, showing efficacy against atypical pain syndromes such as hyperalgesia and allodynia. It is being researched as a potential treatment for neuropathy which can occur as a side effect of some kinds of chemotherapy, as well as showing activity against psoriasis.^[1]^[2]^[3]^[4]

CAS Number

2766800-24-0

PubChem CID

163249803

FormulaC₂₉H₂₈O₆

Molar mass472.537 g·mol⁻¹

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ART26.12

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Identifiers

IUPAC name (2R,4R)-3-(2,3-dihydro-1H-inden-2-yloxycarbonyl)-2,4-bis(2-methoxyphenyl)cyclobutane-1-carboxylic acid
CAS Number	2766800-24-0
PubChem CID	163249803
Chemical and physical data
Formula	C₂₉H₂₈O₆
Molar mass	472.537 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=CC=CC=C1[C@@H]2C([C@H](C2C(=O)OC3CC4=CC=CC=C4C3)C5=CC=CC=C5OC)C(=O)O
InChI InChI=1S/C29H28O6/c1-33-22-13-7-5-11-20(22)24-26(28(30)31)25(21-12-6-8-14-23(21)34-2)27(24)29(32)35-19-15-17-9-3-4-10-18(17)16-19/h3-14,19,24-27H,15-16H2,1-2H3,(H,30,31)/t24-,25-,26?,27?/m1/s1 Key:HFKXLDACQCGGEI-BINWOUKTSA-N