2-Methyl-iPALT
Pharmaceutical compound
From Wikipedia, the free encyclopedia
2-Methyl-iPALT, or 2-methyl-ALiPT, also known as 2-methyl-N-isopropyl-N-allyltryptamine or by its developmental code name ASR-3002, is a serotonin receptor modulator of the tryptamine family.[1] It is the 2-methyl derivative of iPALT.[1] The drug is very similar in structure to 2-methyl-DiPT, which Alexander Shulgin hypothesized would be a DiPT-like selective auditory hallucinogen but never synthesized nor tested.[1]
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| Other names | 2-Me-iPALT; 2-Methyl-ALiPT; 2-Me-ALiPT; ASR-3002; ASR3002; 2-Methyl-N-isopropyl-N-allyltryptamine; 2-Methyl-N-allyl-N-isopropyltryptamine |
| Drug class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist |
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| Formula | C17H24N2 |
| Molar mass | 256.393 g·mol−1 |
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Pharmacology
Pharmacodynamics
2-Methyl-iPALT is a non-selective serotonin receptor agonist, including of the serotonin 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT6 receptors, but not of the serotonin 5-HT1A receptor.[1] However, it shows rather low, micromolar potency for most of these actions, with for example 264-fold lower potency as a serotonin 5-HT2A receptor agonist than the known psychedelic drug 5-MeO-iPALT (ASR-3001).[1] The drug is inactive as a monoamine reuptake inhibitor.[1]
Chemistry
Synthesis
The chemical synthesis of 2-methyl-iPALT has been described.[1]
Analogues
Analogues of 2-methyl-iPALT include 5-MeO-iPALT (ASR-3001), 4-HO-iPALT, 2-methyl-DMT, 2-methyl-DET, and 2-methyl-DiPT, among others.[1][2]
History
2-Methyl-iPALT was patented by the Alexander Shulgin Research Institute (ASRI) in 2024.[1]