ATP5L

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene.^[5][6][7]

AliasesATP5MG, ATP5JG, ATP synthase, H+ transporting, mitochondrial Fo complex subunit G, ATP synthase membrane subunit g, ATP5L

External IDsOMIM: 617473; MGI: 1351597; HomoloGene: 86074; GeneCards: ATP5MG; OMA:ATP5MG - orthologs

Chr.Chromosome 11 (human)^[1]

End118,433,278 bp^[1]

Quick facts ATP5MG, Identifiers ...

ATP5MG
Identifiers
Aliases	ATP5MG, ATP5JG, ATP synthase, H+ transporting, mitochondrial Fo complex subunit G, ATP synthase membrane subunit g, ATP5L
External IDs	OMIM: 617473; MGI: 1351597; HomoloGene: 86074; GeneCards: ATP5MG; OMA:ATP5MG - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,401,346 bp[1] End 118,433,278 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 44,823,855 bp[2] End 44,832,040 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left ventricle mucosa of transverse colon bone marrow cell right auricle of heart renal medulla apex of heart right ventricle myocardium of left ventricle left adrenal gland Top expressed in quadriceps femoris muscle skeletal muscle tissue right kidney heart muscle of thigh yolk sac stomach proximal tubule dentate gyrus of hippocampal formation granule cell neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity transmembrane transporter activity proton transmembrane transporter activity proton-transporting ATP synthase activity, rotational mechanism Cellular component mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex mitochondrion membrane proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Biological process mitochondrial ATP synthesis coupled proton transport ion transport ATP biosynthetic process ATP synthesis coupled proton transport cristae formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10632 27425 Ensembl ENSG00000167283 ENSMUSG00000038717 UniProt O75964 Q9CPQ8 RefSeq (mRNA) NM_006476 NM_013795 RefSeq (protein) NP_006467 NP_038823 Location (UCSC) Chr 11: 118.4 – 118.43 Mb Chr 9: 44.82 – 44.83 Mb PubMed search [3] [4]
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Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the F0 complex.^[7]

The function of subunit G is currently unknown. There is no counterpart in chloroplast or bacterial F-ATPases identified so far.^[8]