ATP6V1F

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.^[5][6][7]

AliasesATP6V1F, ATP6S14, VATF, Vma7, ATPase H+ transporting V1 subunit F

External IDsOMIM: 607160; MGI: 1913394; HomoloGene: 3119; GeneCards: ATP6V1F; OMA:ATP6V1F - orthologs

Chr.Chromosome 7 (human)^[1]

End128,865,847 bp^[1]

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ATP6V1F
Identifiers
Aliases	ATP6V1F, ATP6S14, VATF, Vma7, ATPase H+ transporting V1 subunit F
External IDs	OMIM: 607160; MGI: 1913394; HomoloGene: 3119; GeneCards: ATP6V1F; OMA:ATP6V1F - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 128,862,856 bp[1] End 128,865,847 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 29,467,717 bp[2] End 29,470,511 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex left testis right testis right frontal lobe cingulate gyrus anterior cingulate cortex monocyte nucleus accumbens amygdala right hemisphere of cerebellum Top expressed in right kidney yolk sac human kidney proximal tubule olfactory bulb cerebellum lens urinary bladder dentate gyrus of hippocampal formation granule cell hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding proton-transporting ATPase activity, rotational mechanism proton transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity ATPase activity Cellular component proton-transporting V-type ATPase, V1 domain cytosol proton-transporting two-sector ATPase complex vacuolar proton-transporting V-type ATPase complex membrane extracellular exosome Biological process insulin receptor signaling pathway ion transport transferrin transport phagosome acidification ion transmembrane transport transport proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9296 66144 Ensembl ENSG00000128524 ENSMUSG00000004285 UniProt Q16864 Q9D1K2 RefSeq (mRNA) NM_004231 NM_001198909 NM_025381 RefSeq (protein) NP_001185838 NP_004222 NP_079657 Location (UCSC) Chr 7: 128.86 – 128.87 Mb Chr 6: 29.47 – 29.47 Mb PubMed search [3] [4]
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This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein.^[7]

Subunit F is a 16 kDa protein that is required for the assembly and activity of V-ATPase, and has a potential role in the differential targeting and regulation of the enzyme for specific organelles. This subunit is not necessary for the rotation of the ATPase V1 rotor, but it does promote catalysis.^[8]