Acefylline

Acefylline (INN),^[1] also known as 7-theophyllineacetic acid, is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation etanautine to help offset diphenhydramine induced drowsiness.^[2]

Routes of
administrationIntramuscular, Intravenous

ATC code

• R03DA09 (WHO) (acefylline piperazine)

CAS Number

• 652-37-9 ^N

PubChem CID

• 69550

Quick facts Clinical data, Routes ofadministration ...

Acefylline

Clinical data
Routes of administration	Intramuscular, Intravenous
ATC code	R03DA09 (WHO) (acefylline piperazine)
Identifiers
IUPAC name (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid
CAS Number	652-37-9 N
PubChem CID	69550
ChemSpider	62754 Y
UNII	M494UE2YEP
ChEMBL	ChEMBL70246 Y
CompTox Dashboard (EPA)	DTXSID6057796
ECHA InfoCard	100.010.447
Chemical and physical data
Formula	C9H10N4O4
Molar mass	238.203 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2N(c1ncn(c1C(=O)N2C)CC(=O)O)C
InChI InChI=1S/C9H10N4O4/c1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h4H,3H2,1-2H3,(H,14,15) Y Key:HCYFGRCYSCXKNQ-UHFFFAOYSA-N Y
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A silanol–mannuronic acid conjugate of acefylline, acefylline methylsilanol mannuronate (INCI; trade name Xantalgosil C) is marketed as a lipolytic phosphodiesterase inhibitor. It is used as an ingredient in cosmeceuticals for the treatment of cellulite and as a skin conditioner.^[3][4]