Acetoacetyl-CoA reductase
InterPro Family
From Wikipedia, the free encyclopedia
In enzymology, an acetoacetyl-CoA reductase (EC 1.1.1.36) is an enzyme that catalyzes the chemical reaction
-3-hydroxyacetyl-SCoA.svg)
| acetoacetyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Acetoacetyl-CoA reductase tetramer, Cupriavidus necator | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.36 | ||||||||
| CAS no. | 9028-41-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme are the (R) isomer of a 3-hydroxyacyl derivative of coenzyme A and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are the corresponding 3-oxoacyl derivative of the coenzyme, reduced NADPH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP+-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D(â)-beta-hydroxybutyryl CoA-NADP+ oxidoreductase, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and (R)-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.
See also
- 3-hydroxyacyl-CoA dehydrogenase operating on the enantiomer of the substrate
