Acridone synthase
Class of enzymes
From Wikipedia, the free encyclopedia
Acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction
| Acridone synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.159 | ||||||||
| CAS no. | 99085-53-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme combines one unit of N-methylanthraniloyl-CoA with three of malonyl-CoA to produce one unit of 1,3-dihydroxy-N-methylacridone. Four units of coenzyme A and three of carbon dioxide are byproducts of this polyketide synthesis which leads to rutacridone.[1][2] The enzyme was characterised from the plant Ruta graveolens.[3][4]
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing).[5]
